Peptide Hall of Fame
CHADTIDE
Designer:
Chad Tatko
Structure:
Sequence:
Ac-RWVEVNGOKILQ-NH2
Characteristics:
Chadtide provided the first insights into diagonal cation-pi interactions between Trp2 and Lys9 and lead to many additional mutations for the study of noncovalent interactions, thioether-pi interactions, amide-pi interactions, carbohydrate-pi interactions, and hydrophobic interactions.
References:
C. D. Tatko, M. L. Waters*, "The Geometry and Efficacy of Cation-p Interactions in Diagonal Positions of a Designed β-Hairpin", Protein Science, 2003, 12, 2443-2452.
C. D. Tatko, M. L. Waters*, "Comparison of C-H···π and Hydrophobic Interactions in a β-Hairpin Peptide: Impact on Stability and Specificity", J. Am. Chem. Soc.,2004, 126, 2028- 2034.
C. D. Tatko, M. L. Waters*, "Investigation of the Nature of the Methionine-π Interaction in a β-Hairpin peptide Model System", Protein Science, 2004, 13, 2515-2522.